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DEBRISOQUINE 4-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Cytochrome P-450 CYP2D6
Descriptor
Spanish
:
Citocromo P-450 CYP2D6
Descriptor
Portuguese
:
Citocromo P-450 CYP2D6
Synonyms
English
:
CYP2D6
Debrisoquine Hydroxylase
Debrisoquine 4-Hydroxylase
Tree Number:
D08.244.453.040.600
D08.811.682.690.708.170.040.600
D12.776.422.220.453.040.600
Definition
English
:
A cytochrome P450 enzyme that catalyzes the
hydroxylation
of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian
population.
Entry Combination - descr/qualif
English
:
Cytochrome P-450 CYP2D6
/
antagonists & inhibitors
use
Cytochrome P-450 CYP2D6 Inhibitors
History Note
English
:
97; was DEBRISOQUINE 4-HYDROXYLASE (NM) 1982-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33011
Unique Identifier:
D019389
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS